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2004•Journal of North China Coal Medical CollegeRequires access

The effect of GM-1 on cognitive function after severe traumatic brain injury in rats

Qingjun Liu

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Abstract

Objective To investigate the effect of GM-1 on cognitive function after severe traumatic brain injury in rats. Methods The model of severe closed traumatic brain injury(TBI) was established according to the method created by Marmarou. 48 Wistar rats were divided randomly into TBI group, GM-1 treating group, fake operation group and the normal group, each group has 12 rats. The GM-1 treating group after injury were treated with GM-1 in peritoneum; TBI group, the fake operation group and the normal group were treated with Saline for comparison. 7 days after TBI, their cognitive dysfuction was evaluated using the Morris water maze (MWM). Results GM-1 can shorten obviously the delitescence of Morris water maze tests. Conclusions GM-1 may effectively improve cognitive dyfunction after TBI.

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What this paper is about

Objective To investigate the effect of GM-1 on cognitive function after severe traumatic brain injury in rats. Methods The model of severe closed traumatic brain injury(TBI) was established according to the method created by Marmarou. 48 Wistar rats were divided randomly into TBI group, GM-1 treating group, fake operation group and the normal group, each group has 12 rats. The GM-1 treating group after injury were treated with GM-1 in peritoneum; TBI group, the fake operation group and the normal group were treated with Saline for comparison. 7 days after TBI, their cognitive dysfuction was evaluated using the Morris water maze (MWM). Results GM-1 can shorten obviously the delitescence of Morris water maze tests. Conclusions GM-1 may effectively improve cognitive dyfunction after TBI.

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Available abstract

Objective To investigate the effect of GM-1 on cognitive function after severe traumatic brain injury in rats. Methods The model of severe closed traumatic brain injury(TBI) was established according to the method created by Marmarou. 48 Wistar rats were divided randomly into TBI group, GM-1 treating group, fake operation group and the normal group, each group has 12 rats. The GM-1 treating group after injury were treated with GM-1 in peritoneum; TBI group, the fake operation group and the normal group were treated with Saline for comparison. 7 days after TBI, their cognitive dysfuction was evaluated using the Morris water maze (MWM). Results GM-1 can shorten obviously the delitescence of Morris water maze tests. Conclusions GM-1 may effectively improve cognitive dyfunction after TBI.

Key concepts: Morris water navigation task, Traumatic brain injury, Medicine, Saline, Cognition, Anesthesia, Psychiatry

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