Effect of Trimebutine on gastric receptive relaxation function in functional dyspepsia patients

Objective To evaluate the role of Trimebutine Maleate therapy on functional dyspepsia and its effects on gastric receptive relaxation function.Methods Thirty cases of functional dyspepsia received Trimebutine Maleate treatment by oral administration of 100 mg each time,and 3 times everyday.At the same time other 30 functional dyspepsia cases received Domperidone treatment by oral administration of 10 mg,3 times everyday.Gastric receptive relaxation function,alleviating symptoms of bloating,abdominal pain,early satiety and adverse reactions were evaluated after 4 weeks.Results The total effective rate of Trimebutine Maleate treatment group reached to 87.5%,while Domperidone treatment group was 61.7%.There was a significant difference between Trimebutine Maleate treatment group and Domperidone treatment group(P0.01).The symptom score of pre-cure Trimebutine Maleate treatment(7.0±1.5) were significantly higher than post-cure Trimebutine Maleate treatment(3.2±1.1,P0.01);The symptom score of pre-cure Domperidone treatment(6.9±1.4) were higher than that of post-cure Domperidone treatment(5.0±1.2,P0.05).The symptom score of Trimebutine Maleate treatment group was significantly lower than that of Domperidone treatment group,(P0.01).Both water loading test quantity of pre-cure Trimebutine Maleate treatment(879±152)ml group and pre-cure Domperidone Treatment group(910±202)ml were significantly lower than healthy controls(1 832±185)ml(each P 0.01).In FD group the water loading test quantity had a significant difference before and after Trimebutine Maleate treatments(P0.01).Conclusion Trimebutine Maleate can improve gastric receptive relaxation function of FD patients.Trimebutine Maleate can relieve FD symptoms such as bloating,abdominal pain and early satiety to certain extent.