Effect and safety of trimebutine maleate capsules in treatment of functional dyspepsia

Objective To compare the effect and safety of trimebutine,mosapride and domperidone in the treatment of functional dyspepsia (FD). Methods Two hundred patients with functional dyspepsia were randomly divided into three groups.The patients of trimebutine group were treated with trimebutine,100 mg,three times a day.Mosapride was given 5 mg,three times a day in contrast. The patients of another control group were given each 10 mg domperidone in same way. The course of treatment lasted 4 weeks. Results The total effect rate of treatment group was 87.5%.It was significantly higher than that of domperidone group(61.7%),P 0.01.But there was not differences between trimebutine group and mosapride group(87.5% vs 90.0%),P 0.05 . Adverseactions of trimebutine group were similar to those of mosapride group and domperidone group (P 0.05). Conclusions Trimebutine is shown to be a safe medicine,and it is effective in treatment of FD and similar to mosapride,superior to domperidone.