The effect of chronic intermittent hypoxia on blood glucose and pancreatic islets B-cell ultrastructure in rats

Objective:To set up the rat model ofchronic intermittent hypoxia under normal pressure and studyits effect on the level of blood glucose and pancreatic islet B-cells,ultrstructure.Methods:Rats were respectively exposed to room air 4 weeks(unhandled control,UC),intermittent hypoxia 4 weeks(chronic intermittent hypoxia,CIH),intermittent hypoxia 4 weeks and then room air 4 weeks(restore hypoxia,RH).To test the fasting blood glucose of rats in each group,the fasting blood insulin and C-peptid,and then get the insulin resistance index,and observe the pancreatic islet B-cells under transmission electron microscope.Results:The level of blood glucose of the rats in the CIH group increased significantly compared with those in the UC group and RH group.There was insulin resistance and slight alteration of pancreatic islet B-cells in the CIH group,but there was no difference between UC group and RH group.Conclusion:Chronic intermittent hypoxia can lead to the pancreatic islet B-cell damage and its function disturbance,There was also insulin resistance,which causes the increased level of blood glucose of the rats in the CIH group to increase.