2009•Zhongguo linchuang yixueRequires access

The Endothelial Cell Function in Rats with Chronic Intermittent Hypoxia

Chunxue Bai

Abstract

Objective:To investigate the endothelial cell dysfunction in rats with chronic intermittent hypoxia.Methods:To establish a chronic imtermittent hypoxia(CIH) animal model in rats,in order to mimic the intermittent hypoxia of obstructive sleep apnea-hypopnea syndrome (OSAHS) in humans.Sixteen healthy male SD rats were randomly assigned to two equal groups,the control group and the CIH group.The rats in CIH group were placed in an animal chamber subjected to CIH(nadir ambient oxygen concentration 6%～7%,maximum ambient oxygen concentration 20%～21%,Continuing respectively to 5～7 second) for 8 hours per day (from 9AM to 5PM) and the experimental lasted for 35 days.The rats in control group were placed in the same animal chamber without chronic imtermittent hypoxia.After the experiment,We measured the level of VEGF in plasma by ELISA.Results:VEGF in plasma in CIH group was higher than that in control group,101.08±27.55 vs.52.14±5.68 pg/ml respectively (P0.05).Conclusion:There are endothelial dysfunction in rats with CIH.

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Key concepts: Medicine, Hypoxia (environmental), Obstructive sleep apnea, Intermittent hypoxia, Internal medicine, Endocrinology, Hypopnea, Hypobaric chamber