Antitumor effects of bacailin and its effect on telomerase in tumor cells

Objective To study the inhibitory effect of bacailin on tumor cells and its influence on telomerse activity in Eca-109.Methods The inhibitory effect of bacailin on the proliferation of three kinds of human tumor cells was assayed by MTT method.Transplant tumor models of S 180 and H22 were used.After transplantation the inhibitory rates were calculated.Results Bacailin 20～100 μgml inhibited the proliferation of three kinds of tumor cells in vitro in a dose-dependent manner(P 0.01).The inhibitory rates of bacailin(5,10,20 mgkg IP) in vivo were 29.9%～71.5% and 35.1%～80.6% in tumor-bearing mice with S 180 and H22,respectively.Conclusion Bacailin could inhibit the proliferation of three kinds of tumor cells in vitro and presents antitumor effect on the tumor-bearing mice in vivo.Bacailin can effectively inhibit telomerse activity of tumer cells.