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2004•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

An Experimental Study on Anti-tumor Effect of Matrix Meltaloproteonases Inhibitor

Lin Zhang

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Abstract

Aim To study the anti-tumor effect of matrixmeltaloproteonases inhibitor (ZX-18) in vivo and vitro.Methods The inhibitory effects on proliferation of prostate PC-3 cells,HEPG2 and colorectal adenocarcinomas Lovo were observed by MTT assay in vitro.The S 180 tumor cells were inoculated into the Kunming mice by subcutaneous injection at the right oxter.After that,the weight of tumor was measured.Results ZX-18 could inhibit the proliferation of prostate PC-3 cells,HEPG2 and colorectal adenocarcinomas Lovo significantly in vitro at the concentrations of 0.1,0.2 and 2.0mmol·L -1 in a concentration-dependent manner.In vivo study:at the concentration of 50mg·kg -1 ,ZX-18 had inhibitting effect on tumor growth obviously.Conclusion ZX-18 apparently inhibited the proliferation of tumor cells in vivo and vitro and might be beneficial for the treatment of tumor.

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Aim To study the anti-tumor effect of matrixmeltaloproteonases inhibitor (ZX-18) in vivo and vitro.Methods The inhibitory effects on proliferation of prostate PC-3 cells,HEPG2 and colorectal adenocarcinomas Lovo were observed by MTT assay in vitro.The S 180 tumor cells were inoculated into the Kunming mice by subcutaneous injection at the right oxter.After that,the weight of tumor was measured.Results ZX-18 could inhibit the proliferation of prostate PC-3 cells,HEPG2 and colorectal adenocarcinomas Lovo significantly in vitro at the concentrations of 0.1,0.2 and 2.0mmol·L -1 in a concentration-dependent manner.In vivo study:at the concentration of 50mg·kg -1 ,ZX-18 had inhibitting effect on tumor growth obviously.Conclusion ZX-18 apparently inhibited the proliferation of tumor cells in vivo and vitro and might be beneficial for the treatment of tumor.

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Available abstract

Aim To study the anti-tumor effect of matrixmeltaloproteonases inhibitor (ZX-18) in vivo and vitro.Methods The inhibitory effects on proliferation of prostate PC-3 cells,HEPG2 and colorectal adenocarcinomas Lovo were observed by MTT assay in vitro.The S 180 tumor cells were inoculated into the Kunming mice by subcutaneous injection at the right oxter.After that,the weight of tumor was measured.Results ZX-18 could inhibit the proliferation of prostate PC-3 cells,HEPG2 and colorectal adenocarcinomas Lovo significantly in vitro at the concentrations of 0.1,0.2 and 2.0mmol·L -1 in a concentration-dependent manner.In vivo study:at the concentration of 50mg·kg -1 ,ZX-18 had inhibitting effect on tumor growth obviously.Conclusion ZX-18 apparently inhibited the proliferation of tumor cells in vivo and vitro and might be beneficial for the treatment of tumor.

Key concepts: In vivo, In vitro, Chemistry, Prostate, Subcutaneous injection, Cancer research, MTT assay, Tumor cells

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