Experimental study of Tissue Doppler Tei index in the evaluation of right ventricular function in a rabbit model of pulmonary

Objective To investigate the application value of tissue Doppler echocardiography Tei index in the evaluation of right heart function in a rabbit model of pulmonary hypertension,and to analyze whether nicorandil had a relief effect on pulmonary hypertension caused by right ventricular dysfunction.Methods The subjects were 33 male New Zealand white rabbits,which were randomly divided into three groups:group I,pulmonary hypertensive model group,(pulmonary artery systolic pressure30mmHg);group II,nicorandil-treated group;group III,blank control group(pulmonary vasoconstriction pressure≤30mmHg).The parameters of echocardiography regarding the right ventricular function for for all models were detected,the differences of these indicators between the groups were compared,and the effects of right ventricular Tei index on right ventricular function were analyzed.The standard apical four-chamber view were taken,the maximum movement velocity(Sm)of right atrioventricular ring at right ventricular systolic stage,the maximal exercise(Em)at early diastolic stage,the maximum moving speed(Am)at late diastolic stage,and the Em/Am values were measured.Also,ET and right ventricular Tei index were calculated Results In group I,Em was decreased,Am was increased,and Em/Am ratio was decreased.Compared with that in group III,the right ventricular Tei index in group I was significantly higher(P0.01)and compared with that in group III,the right ventricular Tei index in group II was significantly higher(P0.01).Compared with that in group II,the Tei index in group I was higher,the difference was statistically significant(P0.05).Conclusion TDI technology for measuring right ventricular Tei index in patients with right ventricular dysfunction may be noninvasive,which can rapidly evaluate right ventricular function and has a high application value in clinical treatment.Nicorandil has a certain effect on improving pulmonary hypertension caused by a right heart dysfunction.