Expressions of P16 and △NP63 in cervical intraepithelial neoplasia and carcinoma of cervix uterus and their relationship to clinicopathology

Objective To examine the expression of P16,△NP63 in cervical carcinoma and cervical intraepithelial neoplasia(CIN) and to study the clinlical significance and their correlativity.Methods Expressions of P16 and △NP63 were detected by immunohistochemical staining in 42 cases of cervical squamascarcinoma,90 cases of CIN and 25 cases of chronic cervicitis.Results The positive rate of P16 and △NP63 in CIN and cervical carcinoma was significantly higher than that in chronic cervicitis respectively(P0.01).The level of P16 and △NP63 expression in CIN and cervical carcinoma increased with the increasing of clinical stage(P0.01),and positive staining of △NP63 in well differentiated carcinoma tissue was higher than that in intermediately or poorly differentiated carcinoma tissue.There was no relationship between the expression of P16,△NP63 in cervical carcinoma and the characteristic of clinical or pathology(P0.05).The expression of P16 was positively correlated to △NP63 in CIN and cervical carcinoma(rs=0.6226,P0.01).Conclusion The expressions of P16,△NP63 contribute to carcinogenesis and development of CIN and cervical carcinoma.P16 and △NP63 are of value in early diagnose of CIN and cervical carcinoma.