Effect of hyperuricemia on renal function of elderly patient with early diabetic nephropathy

Objective To discuss the effect of hyperuricemia on 24h urinary albumin,nephropathy index and clinical significance of elderly patients with early diabetic nephropathy.Methods Over 60-year-old patients with early diabetic nephropathy,according serum uric acid level divided into early diabetic nephropathy associated with hyperuricemia(ADU) group(78 cases) and simple diabetic nephropathy(ADN) group(62 cases).Also selected 32 cases elderly normal peoples were as non-diabetic nephropathy(AN) group.Determined the fasting blood glucose,serum creatinine,blood urea nitrogen,24h urine albumin(UAER),nephropathy index of three groups.Results The level of fasting blood glucose and creatinine of each group were statistically significant(P0.05).Uric acid,nephropathy index and UAER of ADU group and ADN group were higher than those of AN group,and those of ADU group were higher than those of ADN group,there were significant difference(P0.05).Elderly patients with early diabetic nephropathy in patients with serum uric acid level and 24h UAER and nephropathy index was positively correlated(r= 0.401,P0.05;r=0.387,P0.05).Conclusion Hyperuricemia in elderly patient with early diabetic nephropathy can increase the glomerular and tubular injury.