Clinic feature and risk factors of type 2 diabetic nephropathy

To investigate the clinical features of type 2 diabetic nephropathy and analyze the risk factors of affecting incidence in order to achieve better prevention and treatment. A retrospective analysis of clinical features of diabetic nephropathy was conducted based on 511 cases in our department from 1997 to 2001. They were 175 diabetes mellitus without nephropathy, 131 early stage diabetic nephropathy, 133 diabetic nephropathy with overt proteinuria, 72 end-stage diabetic nephropathy. Serum levels of lipid, glucose, urea nitrogen, creatinine, uric acid, and blood pressure, albuminuria were monitored in the four groups, and their level were compared. Age, course of disease, hypertension, hyperlipidemia, hyperuricemia, coronary heart disease, biliary calculus, diabetic retinopathy, diabetic peripheral neuropathy, diabetic foot, systolic and diastolic blood pressure were significantly different among four diabetic subgroups (P 0.05). Course of diabetes, systolic blood pressure and hyperlipidemia had significant positive effect on the incidence of diabetic nephropathy (P 0.05). [Conclusion] Dissatisfaction control of blood pressure, blood sugar and lipid result in the progression of diabetic nephropathy. Diabetic nephropathy is closely associated with other vascular complications. Inspecting urine albumium excretion rate periodically, controlling blood pressure and blood sugar strictly and correctting dyslipidemia is an effective way of better prevention and treatment of diabetic nephropathy.