Relationship between integrin alpha-2 gene polymorphisms and cerebral infarction and its effect on plasma lipid levels

Objective To study the relationship between integrin alpha-2(ITGA2) gene C807T polymorphisms and cerebral infarction(CI) and the effect of integrin gene polymorphisms on plasma lipid on lipoprotein levels,and to analyze the nosogenesis of CI.Methods The polymorphism of ITGA2 gene was analyzed by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method in patients with CI group and healthy controls.The plasma lipid and lipoprotein levels were measured by routine method.Results The distributions of ITGA2 gene C807T polymorphism was significantly different between CI group and control group(P0.05),The relative risk suffered from CI of T allele was 1.635 times of the C allele(OR=1.635,95%CI:1.232～2.171),The level of plasma lipid T allele carriers was significantly higher than that of no carriers(P0.05).Conclusions ITGA2 gene C807T polymorphism associates with CI,T allele carrier may be an increasing risk by affecting the levels of plasma lipid and lipoprotein of CI.