2010•Zhongguo jiceng yiyaoRequires access

The relationship of interleukin-18 gene polymorphisms in patients with cerebral infarction and its effect on plasma lipid levels

Junning Chen, Guang-yue Wei, Xue-lin Fu, Zuo-xing Li, Liping Liang

Abstract

Objective To study the relationship of interleukin-18 (IL-18)gene-137G/C polymorphisms in the promoter region with cerebral infarction(CI) and the effect of integrin gene polymorphisms on plasma lipid and lipoprotein levels. Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) were used for the detection of integrin genotypes in 190 patients with CI and 210 healthy controls. The plasma lipid and lipoprotein levels were measured by routine method. Results The distributions of IL-18 gene -137G/C polymorphism was significantly different between CI group and control group(P ＜0. 05＝ ,The relative risk suffered from CI of C allele was 1.624 times of the G allele (OR = 1.624,95% CI: 1.134 ～ 2.324), The level of plasma lipid C allele carriers was significantly higher than no carriers(P ＜0.05＝. Conclusion IL-18 gene-137G/C polymorphism was associated with CI, C allele may be genetic susceptibility gene for CI. Key words: Brain infarction; Interleukin-18; Gene polymorphism; Plasma lipid

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Key concepts: Genotype, Allele, Medicine, Restriction fragment length polymorphism, Internal medicine, Gene, Lipid profile, Molecular biology