Correlation between ApoH gene promoter 32 polymorphism and cerebral infarction

Objective To investigate the gene polymorphism and the distribution of allele of apolipoprotein H(ApoH) gene promoter 32, and to evaluate the correlation between the gene polymorphism and cerebral infraction(CI).Methods The gene ApoH promoter 32 polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) in 278 CI patients and 195 age-matched controls. The results of PCR-RFLP were further confirmed by gene sequencing. Results The blood glucose, serum TG, TC, LDL-C and blood pressure in CI patients were significantly higher than those in healthy controls(P0.05). The A allele frequency in CI patients was 6.12% while that in healthy controls was 6.67%. There was no significant difference in genotype and allele distribution between CI patients and healthy controls(P0.05). A significant difference in level of serum LDL-C between CC and CA genotype was seen only in female patients. Conclusions The ApoH promoter 32 polymorphism had no correlation with cerebral infarction, but might have some correlation with metabolism of serum lipids.