2011•PubMedRequires access

[Expression of ID3 protein in prostate cancer and its clinicopathological significance].

Kai Wang, Xiaojun Li, Hong-Lin Yin, Hang‐bo Zhou, Fangfang Chen, Hai Wang, Heng‐hui Ma

Abstract

OBJECTIVE: To study the expression of the ID3 protein in prostate cancer and its clinicopathological significance. METHODS: We detected the expression of the ID3 protein in PC-3M cells by indirect immunofluorescence, and that in 29 prostate cancer and 15 prostate hyperplasia specimens by immunohistochemistry. Then we analyzed the correlation between the expression level of ID3 and the clinicopathological parameters. RESULTS: The ID3 protein was expressed predominantly in the nucleus of PC-3M cells. Its expression rate was 82.7% (24/29) in the prostate cancer specimens, significantly higher than 6.6% (1/15) in prostate hyperplasia (P < 0.05), and was positively correlated with the Gleason score of prostate cancer (P < 0.05). CONCLUSION: The ID3 protein is expressed in prostate cancer, and is elevated with the increase of Gleason score.

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Key concepts: Prostate cancer, Immunohistochemistry, Hyperplasia, Prostate, Medicine, PCA3, Immunofluorescence, Oncology