Analysis of chromosome karyotypes of 90 dysplastic patients.

Objective:To analyze the relationship between abnormal karyotypes and abnormal fertility.Methods:By investigating 2,485 genetic counseling patients in the Institute for Reproductive Medicine of Jilin Province,from May 8,2004 to May 17,2008.Their peripheral blood lymphocytes were cultured and the abnormal karyotype were analyzed.Results:There were 257 cases of abnormal karyotypes in 2,485 patients with genetic counseling and the abnormal rate is 10.34%.In chromosomal abnormal karyotypes,there were 154 cases of sex chromosome abnormalities,accounting for 59.92%;and there were 103 cases of euchromosome abnormalities,accounting for 40.08%.And there were 90 cases of dysplasia,accounting for 35.02%.Conclutions:Abnormal karyotype is closely related to dysplasia,karyotype analysis is conducive to clinical diagnosis,but also provide the basis for genetic counseling.