Plasma Coagulation Factors in Patients With Cirrhosis

Objective The plasma coagulation factors were evaluated in 60 patients with liver cirrhosis. Methods The blood prothrombin time(PT),activated partial thromboplastin time(APTT) and plasma fibrinogen level(FIB) were determined by coagulant turbidity method.Blood platelet count(PLT) was measured with ABBOTT CELL-DYN1600 automatic blood cell counter.The activities of coagulation factors were detected by one clotting stage method. Results The PT and APTT in patients with cirrhosis were significantly prolonged than that of normal controls as well as the decrement of FIB level and PLT count(P0.05).The activity of factor Ⅷ was elevated.In contrast,the activities of other coagulation factors,such as FⅡ,FⅤ,FⅦ,FⅨ,FⅪ,FⅫ were decreased﹙(P0.05). Conclusion The PT and APTT interval,the levels of FIB and PLT count and all other coagulation factors are abnormal in patients with hepatic cirrhosis,they are valuable in identifying coagulation disorders,characterizing the degree of liver damage,predicting bleeding tendency and estimating prognosis.