The safety and efficacy of terbinafine in the treatment of severe tinea manuum and tinea pedis

Objective To study the efficacy and safety of terbinafine in the treatment of tinea manuum and tinea pedis.Metheods One hundred and twenty cases of tinea manuum and tinea pedis were randomly divided into two groups.The study group was treated with oral terbinafine 250 mg daily,and terbinafine ointment 0.1% twice daily,continuously for 3 weeks.The control group was only treated with terbinafine ointment 0.1%,twice daily for continuously 3 weeks.After 2 weeks of stopping treatment,we observed clinical cure rates,and after 7 weeks,the recurernce rate.Results In the study group,the total clinical cure rate was 95% and the mycology clearance rate 95%.The incidence of adverse events was 5%.The majority were gastrointestinal disorders.In the control group,the total clinical cure rate was 40% and the total mycology clearance rate 75%,After 4 weeks of stopping treatment,the recurernce rate was zero in the study group and 20% in the control group.Conclusion Treating severe tinea manunm and tinea pedis with oral terbinafine and terbinafine ointment 0.1% is safe and effective.