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Significance of testing GLUT1 with PCNA in pathological tissues of endometrial hyperplasia and endometrial carcinoma.

Liang Yan-hon

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Abstract

Objective To explore the significance of testing GLUT1 with PCNA in pathological tissues of endometrial hyperplasia and endometrial carcinoma.Methods Collecting 110 lesion specimens of endometrial hyperplasia and endometrial carcinoma,testing GLUT1 and PCNA by SP method,and analyzing their correlation.Results The positive rate of GLUT1 was 26.67%,57.78%,81.54% respectively in normal proliferative endometrium,atypical endometrial hyperplasia and endometrial carcinoma,showing an increasing trend,and the positive rate of PCNA also showed the same increasing trend.There were significant differences(P0.01),and the two indicators had positive correlation(r=0.41,P0.01).Conclusion GLUT1 and PCNA have close relationship with endometrial hyperplasia and endometrial carcinoma,and they can reflect the progression of lesions,even testing GLUT1 with PCNA can be used to evaluate the proliferation index and biological behavior of the lesion.

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What this paper is about

Objective To explore the significance of testing GLUT1 with PCNA in pathological tissues of endometrial hyperplasia and endometrial carcinoma.Methods Collecting 110 lesion specimens of endometrial hyperplasia and endometrial carcinoma,testing GLUT1 and PCNA by SP method,and analyzing their correlation.Results The positive rate of GLUT1 was 26.67%,57.78%,81.54% respectively in normal proliferative endometrium,atypical endometrial hyperplasia and endometrial carcinoma,showing an increasing trend,and the positive rate of PCNA also showed the same increasing trend.There were significant differences(P0.01),and the two indicators had positive correlation(r=0.41,P0.01).Conclusion GLUT1 and PCNA have close relationship with endometrial hyperplasia and endometrial carcinoma,and they can reflect the progression of lesions,even testing GLUT1 with PCNA can be used to evaluate the proliferation index and biological behavior of the lesion.

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Available abstract

Objective To explore the significance of testing GLUT1 with PCNA in pathological tissues of endometrial hyperplasia and endometrial carcinoma.Methods Collecting 110 lesion specimens of endometrial hyperplasia and endometrial carcinoma,testing GLUT1 and PCNA by SP method,and analyzing their correlation.Results The positive rate of GLUT1 was 26.67%,57.78%,81.54% respectively in normal proliferative endometrium,atypical endometrial hyperplasia and endometrial carcinoma,showing an increasing trend,and the positive rate of PCNA also showed the same increasing trend.There were significant differences(P0.01),and the two indicators had positive correlation(r=0.41,P0.01).Conclusion GLUT1 and PCNA have close relationship with endometrial hyperplasia and endometrial carcinoma,and they can reflect the progression of lesions,even testing GLUT1 with PCNA can be used to evaluate the proliferation index and biological behavior of the lesion.

Key concepts: Medicine, GLUT1, Proliferating cell nuclear antigen, Endometrial hyperplasia, Carcinoma, Atypical hyperplasia, Pathological, Hyperplasia

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Significance of testing GLUT1 with PCNA in pathological tissues of endometrial hyperplasia and endometrial carcinoma. — Research Paper | ScholarLens