Clinic significance of combination of human papillomavirus DNA test and ThinPrep liquid based cytology in diagnosis of early cervical cancer and precancer lesions

Objective To investigate clinic significance of human papillomavirus DNA testing and Thinprep liquid based cytology in diagnosis of early cervical cancer and precancer lesions.Methods A total of 4 248 women with high risk factors were tested for high-risk types of HPV by Hybrid Capture Ⅱ(HC-Ⅱ) assay.Women with positive HPV DNA underwent a ThinPrep liquid based cytology test(TCT).Women with positive HPV DNA and TCT were referred for colposcopy and biopsy.Results A total of 1 682(38.32%) women were proved to have been infected by high-risk HPV,aged(33.68±9.60)years(19～60 years),33.3%(537/1 628) of which were younger than 30 years old. Among the 250 women with positive HPV and positive TCT received colposcopy and biopsy,151 were CINⅠ,34 CINⅡ,25 CINⅢ and 13 invasive cervical cancer.Conclusions HPV DNA testing may increase sensitivity of cytologic screening.Combination of HC-Ⅱ and TCT is the optimal approach for diagnosis of early cervical cancer and precancer Lesions.HPV DNA testing may forewarn CIN.