Effect observation of omeprazole,levofloxacin and amoxicillin in treatment of peptic ulcer

Objective To observe the eradication effect of omeprazole,levofloxacin and amoxicillin triple therapy for helicobacter pylori(Hp)and the therapeutic effect for peptic ulcer(PU).Methods 115 cases of H.pylori-positive PU patients were randomly divided into observation group(59 cases)and control group(56 cases).The observation group gaven omeprazole 20mg,once a day;Levofloxacin 500mg,once a day;Amoxicillin 1000mg,2 times a day.While control group gave omeprazole 20mg,2 times a day;Clarithromycin 500mg,2 times a day;Amoxicillin 1000mg,2 times a day.Two groups all ate before meals,7d for a course of treatment.Withdrawal after 4 weeks,reviewed endoscopy.Results Recovery rate and efficient rate of two group respectively were 86.4%,93.2% and 57.1%,62.5%,the difference had a statistical significance(P0.05);The eradication rate and reduce rate of hewlett-packard in observation graup were higher than that in control group(88.1% vs 58.9%,91.5% vs 66.1%),the differences were statistical significance(P0.05).Conclusion Omeprazole,levofloxacin and amoxicillin triple therapy for PU had merits of a short couse,high efficacy,good compliance,reasonable drug prices and cound be widely used in basic-level hospitals.