Efficacy and safety of salmeterol fluticasone plus montelukast sodium in the treatment of variant asthma in children

Objective To explore the clinical curative effect and safety of salmeterol fluticasone plus montelukast sodi um in the treatment of variant asthma(VA) in children.Methods A total of 124 cases of variant asthma were analyzed from April 2008 to April 2012.They were divided into treatment group(64 cases),which used salmeterol fluticasone plus mon telukast sodium,and control group(60 cases),which used tsalmeterol fluticasone.There were 6 months for one course in both groups.Lung function changes,the overall clinical curative effect and safety issues in both groups were ob served.Results(1) The standard rate of lung function of two groups before treatment were 25.0% and 23.3%.There was no statistically significant(P 0.05).The standard rate were 67.2% and 41.4% after treatment 3 month,79.7% and 57.1% after 6 month,87.5% and 65.0% after 12 month.There was statistically significant between two groups(P 0.05).(2) The total effective rate between control group and treatment group were 95.3%(61/64),80.0%(48/60).There was statistically significant differences between two groups(χ2=6.828,P 0.01).(3) The relapse rate between control group and treatment group were 4.7%,18.6%.There was statistically significant between two groups(P 0.05).Conclusion The application of salmeterol fluticasone plus montelukast sodium in the treatment of variant asthma in chil dren can increase the pulmonary function in patients,improve clinical efficiency,and reduce the recurrence of the dis ease.It’s worthy of clinical application.