Comparative Clinical Observation on the Effect of Combination of Omeprazole and Motilium with Jiangni Decoction on Reflux Esophagitis

To investigate the effects of combination of omeprazole and motilium with Jiangni Decoction on reflux esophagitis and on motilin and gastrin. 120 cases were randomly divided into three groups Chinese medicine group(Jiangni Decoction n=40),western medicine group(omeprazole and motilium ,n=40), and combination therapy group(Jiangni Decoction, omeprazole and motilium ,n=40). All cases were treated for 4 weeks. The symptoms and gastroscopic feature were observed and recorded. Serum levels of motilin and gastrin were measured before and after treatment. The curative effect of combination therapy(effective rate 97.5%) was higher than that of single therapy with Jiangni Decoction(75%)or omeprazole and motilium(80%). Motilin[(182.6±43.9)pg/mL] and gastrin[(99.2±31.7 )pg/mL]in reflux esophagitis cases were lower than those in normal control group [(326.6±58.4) pg/mL and (163.1±28.7)pg/mL respectively]. Serum levels of motilin and gastrin increased significantly in three groups after treatment, with the highest level in the combination therapy group. [Conclusion]Omeprazole and motilium and Jiangni Decoction are effective drugs for reflux esophagitis. Combination therapy can not only improve the effect but also promote gastrointestinal motility.