COMPARATIVE CLINICAL OBSERVATION ON THE EFFECT OF COMBINATION OF WESTERN MEDICINE AND CHINESE HERB ON REFLUX ESOPHAGITIS.

Objective:To investigate the effects of combination of Omeprazole and Motilium with Jiangni Decoction on reflux esophagitis and on Motilin complicated with Gastrin.Methods:120 cases were randomly divided into three groups-Chinese medicine group(Jiangni Decoction),western medicne group(omeprazole and motilium) and combinative group(omeprea 20/e and Motilium with Jiangni decoction),All cases were treated for 4 weeks.The symptoms and gastroscopic feature were observed and recorded.Serum levels of Motilin and Gastrin were measured before and after treatment.Results:The curative effect of combination therapy(effective rate 97.5%) was higher than that of single therapy with Jiangni Decoction(75%) or Omeprazole complicated with Motilium(80%),Motilin[(182.6±43.9)pg/ml]and Gastrin[(99.2±31.7)pg/ml]in reflux esophagitis cases were lower than those in normal control group[(326.6±58.4pg/ml]and [(163.1±28.7)pg/ml]respectively.Serum levels of Motilin and Gastrin increased significantly in three groups after treatment,and the highest level in the combination therapy group.Conclusion:Omeprazole complicated with Motilium or Jiangni Decoction is effective drugs for reflux esophagitis.Combination therapy can not only improve the effect but also promote gastrointestinal motility.