The expressions of HER-2,p16 and p53 protein in infiltrating ductal breast carcinoma and its significance

Purpose To investigate the expressions of HER-2,p16 and p53 protein in breast infiltrating ductal carcinoma and its clinical significance.Methods 149 patients were confirmed as breast infiltrating ductal cancer and were selected in our study which hospitalized from July in 2008 to December in 2010.Then pathologic and clinical data of patients were collected and the expressions of HER-2,p16 and p53 protein in breast infiltrating ductal cancer and normal tissues was detected.Results The positive rate of HER-2,p16 and p53 protein in breast infiltrating ductal cancer was 23.5%,31.5% and 51.0%,repectively.Over-expression of HER-2 had a significant correlation with axillary lymph node metastasis and histological grade(χ2=5.687,χ2=5.924,both P0.05).There was significant difference in the positive expression of p16 between the different age groups(χ2=4.213,P0.05).And there was significant difference in the positive expression of p53 between different histological grading(χ2=6.378,P0.05).There was a significant correlation between the expressions of HER-2,p16 and disease-free survival time after operation.There was significant correlation between p16 and p53(r= 0.282,P0.05).Conclusions The expressions of HER-2,p16,and p53 protein are closely related with the development of breast invasive ductal cancer and thus they could be used as an important indicator for guiding treatment and predicting prognosis.