Lead-Eliminating Effect of a Lead-Excreting Food on Lead Poisoning in Mice

Objective To evaluate the lead-eliminating effectiveness of a lead-excreting food on lead poisoning in mice.Methods Ninety Kunming male mice with body weight of 18-22 g were randomly divided into six groups:negative control group,lead poisoning model group,positive control(lead-eliminating medicine) group,and low,medium and high dose lead-excreting food treated groups.Except the negative control group freely drinking deionized water,other groups were drinking water contained 1.00 g /L of lead acetate freely for 30 days for lead exposure.The mice in treated groups were given the lead-excreting food by gavage,based on 5-,10-and 20-fold of the recommended dosage for human consumption(0.60 g/(kgBW·d)).The mice in the positive control group were given dimercaptosuccinic acid(DMSA) solution,and the mice in model control group and negative control group were given deionized water by gavage.The lead content of whole blood,liver,femur,kidney and brain was determined a month later.Results The lead content in blood,liver,kidney and brain of the three lead-excreting food treated groups was significantly lower than that of the lead poisoning model group(P 0.05 or P 0.01);The lead content in the femur of high and medium dose lead-excreting food groups was significantly lower than the lead poisoning model group(P 0.01).Conclusion The lead-excreting food is effective in eliminating lead from mice.