2008•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access
Expression of HIF-1α, VEGF in gastric carcinoma and relationship with microvessel density( MVD)
Qiang Wang
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Abstract
[Objective] To study the expression of HIF-1α、VEGF and MVD in gastric cancer and their relationship with tumor angiogenesis,clinicopathologic feature and prognosis. [Methods] Immunohistochemical technique was used to detect the expression of HIF-1α and VEGF in 54 cases of gastric cancer, the microvessel density(MVD) marked by CD34 was detected.The relationship between the expression of HIF-1α, VEGF and tumor angiogenesis, clinicopathologic feature of patients was analyzed. [Results] The positive expression rate of HIF-1α in gastric cancer (74.07%) was significantly higher than that in normal gastric tissue (0%), (P 0.01); The expression of HIF-1α in gastric cancer was significantly associated with TNM stage, invasive depth and lymph-node metastasis, (P 0.05). The positive expression rate of VEGF in gastric cancer (68.5%) was significantly higher than that in normal gastric tissue (13.3%), (P 0.01). The expression of VEGF in gastric cancer was significantly associated with TNM stage, invasive depth, lymph-node metastasis and tumor size, (P 0.05). The MVD of gastric cancer (31.5±7.1) was significantly higher than that in normal gastric tissue(6.7±2.4), (P 0.01). The MVD of gastric cancerwas was significantly associated with TNM stage, invasive depth and lymphnode metastasis, (P 0.05). There was a positive correlation between expression of HIF-1α and VEGF, as well as HIF-1α and MVD. [Conclusion] HIF-1α, VEGF and MVD play the very important role in the development in gastric cancer, could be a factor in diagnosis of gastric cancer and estimation of prognosis.