Expression of tumor marker p16 and p53 proteins in lung adenocarcinoma tissues

Objective: To study expression of tumor marker P16 and P53 proteins in the occurrence and development of lung adenocarcinoma.Methods:p16 and p53 genes expressions were detected in 57 lung adenocarcinoma and pericarcinoma tissues by immunohistochemical method.The data were analyzed with clinical materials.Results: The positive rate of P16 protein expression was 21.1%(12/57) in lung adenocarcinoma samples and was significantly lower than that in the pericarcinoma tissues 59.6%(34/57).The positive rate of P53 protein expression was 80.7%(46/57) in lung adenocarcinoma tissue,and significantly higher than those in pericarcinoma tissues(42.1%,24/5,P0.05).The positive expressions of the P16 and P53 proteins were correlated with histological type and degree of differentiation of lung adenocarcinoma and depth of invasion and lymph node metastasis(P0.05).Conclusions: The data suggest that abnormal expressions of tumor marker P16 and P53 proteins are closely correlated with the occurrence and development,malignancy degree,lymph node metastasis and prognosis of lung adenocarcinoma.