2004Shanghai Laboratory Animal ScienceRequires access

Acute Toxicity and Dermal Sensitization of Bacillus thuringiensis Original Drug

Xinyue Yang

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Abstract

According to toxicological test methods of pesticides for registration(GB15670-1995),The test of acute toxicity of biopesticide - bacillus thuringiensis, include acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, acute eye irritation test and dermal sensitization were carried out. The acute oral toxicity LD50 of this biopesticide was 3830 mg/kg in male and 3160 mg/kg in female, acute dermal toxicity LD50(4h)2 150 mg/kg, LC50(2h)5 000 mg/m3, there is no irritation to rabbit eye, dermal sensitization : rate of sensitization is zero.So the acute oral toxicity , acute dermal toxicity and acute inhalation toxicity of bacillus thuringiensis are lower. There is no irritation to rabbit eye, and it belongs to grade I weak sensitizing matter.

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What this paper is about

According to toxicological test methods of pesticides for registration(GB15670-1995),The test of acute toxicity of biopesticide - bacillus thuringiensis, include acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, acute eye irritation test and dermal sensitization were carried out. The acute oral toxicity LD50 of this biopesticide was 3830 mg/kg in male and 3160 mg/kg in female, acute dermal toxicity LD50(4h)2 150 mg/kg, LC50(2h)5 000 mg/m3, there is no irritation to rabbit eye, dermal sensitization : rate of sensitization is zero.So the acute oral toxicity , acute dermal toxicity and acute inhalation toxicity of bacillus thuringiensis are lower. There is no irritation to rabbit eye, and it belongs to grade I weak sensitizing matter.

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Available abstract

According to toxicological test methods of pesticides for registration(GB15670-1995),The test of acute toxicity of biopesticide - bacillus thuringiensis, include acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, acute eye irritation test and dermal sensitization were carried out. The acute oral toxicity LD50 of this biopesticide was 3830 mg/kg in male and 3160 mg/kg in female, acute dermal toxicity LD50(4h)2 150 mg/kg, LC50(2h)5 000 mg/m3, there is no irritation to rabbit eye, dermal sensitization : rate of sensitization is zero.So the acute oral toxicity , acute dermal toxicity and acute inhalation toxicity of bacillus thuringiensis are lower. There is no irritation to rabbit eye, and it belongs to grade I weak sensitizing matter.

Key concepts: Acute toxicity, Toxicity, Sensitization, Irritation, Eye irritation, Bacillus thuringiensis, Biopesticide, Pharmacology

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