Prevalence and distribution of HPV multiple infection in various cervical lesions

Objective To study the relationship between of multiple HPV infection and the pathogenesis and development of in cervical lesion.Methods270 cases with cervical lesion(in clude 130 CINⅠ69CINⅡ,48CINⅢ and 40 cervical cancer) were chosen,liquid-basted cytology of which were collected,to detect the HPV genetyping,and then compared with the cervical biospy.Results HPV infection rate of the 287 samples was 89.9% and the multiple infection rate of HPV in CINⅠ,CINⅡ,CINⅢ and cervical squamous carcinoma were 48.6%,40.3%,31.1% and 27.5%.Statistics difference was noted between the cases of CINⅠand CINⅢ,cervical squamous carcinoma(P0.05).The multiple infection of HPV had a very high prevalence rate(48.1%) in the group under 40 years of age.Conclusions The severity of cervical lesions may not rely on the quantity of the HPV multiple infection but depend on the virulence of HPV genetype.