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2013•Harbin Yike Daxue xuebaoRequires access

Expression of MUM-1 of R-S cells in classical Hodgkin lymphoma and its significance

DU Jin-rong

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Abstract

Objective To explore the expression and significance of MUM-1 of Reed-Sternberg cells(R-S cells) in classical Hodgkin lymphoma(CHL).Methods MUM-1 in 30 cases of CHL were immunohistochemically stained with SP method.The expression of MUM-1 of R-S cell was observed and compared with the expression of CD30,CD15 and pax-5 in R-S cells.Results In all cases of CHL,the intensity of expression of MUM-1 was significantly higher than that of CD30 and CD15.All 30 cases(100%) of CHL showed an intensely caryon staning,while 29 among them(96.7%) for CD30 and 22(73.3%) of 30 cases for CD15 showed weak-to-strong expression,and pax-5 showed weak expression in 25(83.3%) cases.Conclusion MUM-1 is a highly sensitive marker for Reed-Sternberg cells,which is helpful to diagnosis of classical Hodgkin lymphoma and has a high negative predictive value for excluding the classical Hodgkin lymphoma.

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Objective To explore the expression and significance of MUM-1 of Reed-Sternberg cells(R-S cells) in classical Hodgkin lymphoma(CHL).Methods MUM-1 in 30 cases of CHL were immunohistochemically stained with SP method.The expression of MUM-1 of R-S cell was observed and compared with the expression of CD30,CD15 and pax-5 in R-S cells.Results In all cases of CHL,the intensity of expression of MUM-1 was significantly higher than that of CD30 and CD15.All 30 cases(100%) of CHL showed an intensely caryon staning,while 29 among them(96.7%) for CD30 and 22(73.3%) of 30 cases for CD15 showed weak-to-strong expression,and pax-5 showed weak expression in 25(83.3%) cases.Conclusion MUM-1 is a highly sensitive marker for Reed-Sternberg cells,which is helpful to diagnosis of classical Hodgkin lymphoma and has a high negative predictive value for excluding the classical Hodgkin lymphoma.

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Available abstract

Objective To explore the expression and significance of MUM-1 of Reed-Sternberg cells(R-S cells) in classical Hodgkin lymphoma(CHL).Methods MUM-1 in 30 cases of CHL were immunohistochemically stained with SP method.The expression of MUM-1 of R-S cell was observed and compared with the expression of CD30,CD15 and pax-5 in R-S cells.Results In all cases of CHL,the intensity of expression of MUM-1 was significantly higher than that of CD30 and CD15.All 30 cases(100%) of CHL showed an intensely caryon staning,while 29 among them(96.7%) for CD30 and 22(73.3%) of 30 cases for CD15 showed weak-to-strong expression,and pax-5 showed weak expression in 25(83.3%) cases.Conclusion MUM-1 is a highly sensitive marker for Reed-Sternberg cells,which is helpful to diagnosis of classical Hodgkin lymphoma and has a high negative predictive value for excluding the classical Hodgkin lymphoma.

Key concepts: CD15, Classical Hodgkin lymphoma, CD30, Reed–Sternberg cell, Hodgkin lymphoma, Lymphoma, Hodgkin's lymphoma, Tumor cells

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