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THE INFLUENCE OF IRBESARTAN ON URINARY TRANSFORMING GROWTH FACTOR-β_1 IN EARLY DIABETIC NEPHROPATHY

Ganxiong Liang

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Abstract

Objective To observe the influence of irbesartan on urinary transforming growth factor-beta1(TGF-β_1) in early diabetic nephropathy and explore their therapeutic mechanism. Methods Seventy-tow type 2 diabetic patients with early diabetic nephropathy were randomly divided into control group and irbesartan treatment group. Urinary albumin excretion and urinary TGF-β_1 was measured. Results Urinary albumin excretion and urinary TGF-β_1 levels in irbesartan treatment group were significantly decreased after 12 weeks treatment. Conclusion Irbesartan have renoprotective effect in patients with early diabetic nephropathy. The decrease of TGF-β_1 concentration in renal tissue may be a mechanism for this action.

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What this paper is about

Objective To observe the influence of irbesartan on urinary transforming growth factor-beta1(TGF-β_1) in early diabetic nephropathy and explore their therapeutic mechanism. Methods Seventy-tow type 2 diabetic patients with early diabetic nephropathy were randomly divided into control group and irbesartan treatment group. Urinary albumin excretion and urinary TGF-β_1 was measured. Results Urinary albumin excretion and urinary TGF-β_1 levels in irbesartan treatment group were significantly decreased after 12 weeks treatment. Conclusion Irbesartan have renoprotective effect in patients with early diabetic nephropathy. The decrease of TGF-β_1 concentration in renal tissue may be a mechanism for this action.

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Available abstract

Objective To observe the influence of irbesartan on urinary transforming growth factor-beta1(TGF-β_1) in early diabetic nephropathy and explore their therapeutic mechanism. Methods Seventy-tow type 2 diabetic patients with early diabetic nephropathy were randomly divided into control group and irbesartan treatment group. Urinary albumin excretion and urinary TGF-β_1 was measured. Results Urinary albumin excretion and urinary TGF-β_1 levels in irbesartan treatment group were significantly decreased after 12 weeks treatment. Conclusion Irbesartan have renoprotective effect in patients with early diabetic nephropathy. The decrease of TGF-β_1 concentration in renal tissue may be a mechanism for this action.

Key concepts: Irbesartan, Diabetic nephropathy, Medicine, Urinary system, Internal medicine, Urology, Endocrinology, Excretion

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THE INFLUENCE OF IRBESARTAN ON URINARY TRANSFORMING GROWTH FACTOR-β_1 IN EARLY DIABETIC NEPHROPATHY — Research Paper | ScholarLens