2010•Pharmacy and Clinics of Chinese Materia MedicaRequires access

Effects of puerarin on cardiac shape and function in myocardial hypertrophy induced by levothyoxine in rat

Meng Ya-peng

Abstract

Objective:To explore the effect of puerarin(Pue)on cardiac shape and function in myocardial hypertrophy(MH)induced by levothyoxine(Lev).Method:The MH model was established by hypodermic injection of levothyoxine in SD rats.Pue was given to rats orally(100mg·kg-1)for 10 days,and rat blood pressure was monitored.The rat cardiac function,collagen and Ca2+ concentration of cardiac cell were measured.Result:Compared with Lev group,Pue significantly decreased the blood pressure,collagen and Ca2+concentration.Conclusion:These results indicate that Pue has some certain function in inhibiting myocardial hypertrophy induced by Lev.

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Key concepts: Puerarin, Myocardial hypertrophy, Cardiac hypertrophy, Cardiac function curve, Blood pressure, Muscle hypertrophy, Internal medicine, Medicine