2001•Zhongguo yaolixue yu dulixue zazhiRequires access
Relationship between experimental cardiac hypertrophy and concentration of 5-hydrotryptamine in myocardial tissue of rats
Ming Zhao
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Abstract
To study the changes in 5-hydro- tryptamine (5-HT) and angiotensin-Ⅱ(Ang-Ⅱ) concentration in myocardial tissue of rats with cardiac hypertrophy and to elucidate the relationship between concentrations of 5-HT,Ang-Ⅱ and cardiac hypertrophy, rats were clipped in aorta and injected thyroxine(0.4 mg·kg -1, ip, once a day for 2-4 weeks) to establish pressure overload- and endocrine-induced cardiac hypertrophy model respectively. Radioimmunity and photometry were used to measure concentration of 5-HT and Ang-Ⅱ in myocardial tissue. After the aortae were clipped 4, 6, 8 weeks or the rats were injected thyroxine 2, 3, 4 weeks, 5-HT and Ang-Ⅱ were measured in myocardial tissue. The results showed that the symptom of cardiac hypertrophy appeared significantly, the concentrations of 5-HT and Ang-Ⅱ increased markedly, showing the positive correlation between 5-HT concentration and the degree of cardiac hypertrophy. The results suggest that 5-HT be involved in pathogenesis of myocardial hypertrophy and the further study should be carried to elucidate their relationship.