Radiosensitivity on Nasopharyngeal Carcinoma by CMNa

Objective To evaluate the radiosensitivity and toxicity of CMNa on local advanced nasopharyngeal carcinoma. Methods 40 patients with local advanced nasopharyngeal carcinoma were divided into two groups randomly: treatment group (n=20) and control group (n=20). The patients in treatment group were intravenous dripped CMNa 800mg/m 2 three times weekly during whole treatment period by nasopharyngeal carcinoma. Patients in control group were treated with radiotherapy alone. The method of radiotherapy in control group was as same as that in treatment group. The doses for primary lesion and neck metastatic lesion were 7 000~7 400cGy/35~37f/7~ 7.5w. Results For primary lesion, the complete regression (CR) rates in treatment group and in control group were 95.0% and 85.0% respectively, and the doses by which the effects had reached CR were 4905.0cGy and 5835.6cGy respectively. That doses of neck metastatic lesion in the two groups were 4500.0cGy and 5342.8cGy respectively. In the two groups, there were significante difference in the doses by which the effects had reached CR, while no significante difference in toxicity. The toxicity of nerve system was not observed in the two groups. Conclusion Our study suggests that CMNa should enhance radiosensitivity on nasopharyngeal carcinoma, increase the short-term therapeutic response and decrease the radiotherapy dose without obvious toxicity.