Efficacy of antibiotics applied for prevention of incision infections in general surgery patients during perioperative period

OBJECTIVE To compare the effects of perioperative application of antibiotics and postoperative application of antibiotics in the prevention of incision infection in general surgery department,and to explore the clinical value of application of antibiotics during perioperative period.METHODS A total of 520 patients who underwent general surgery were randomly selected and divided into the observation group and control group with 260 cases in each.According to Guidelines for Clinical Application of Antibiotic,the observation group was treated with cefazolin or cefuroxime;the control group did not use antibiotics before or during the operation,postoperative application of cefazolin or cefuroxime was performed through intravenous infusion.RESULTS The rate of fever in the observation group was 16.54%,antipyretic time was(4.12±2.34)d,the rate of incision infection was 1.92%,as compared with the control group,the differences were not statistically significant.The hospitalization duration of the observation group was(8.23 ±2.34)d which was shorter than(11.78±3.17)d of the control group,the difference was statistically significant(P0.05).CONCLUSION Preoperative use of single agent and postoperative use of antibiotics in a limited time is an effective and feasible model to prevent incision infection and is worthy of being promoted in clinic.