Clinical observation on application of antibiotics to prevent incision infections during perioperative period of orthopaedics surgery

OBJECTIVE To observe the clinical effect of standardized use of antibiotics to prevent incision infections during perioperative period.METHODS A total of 580 patients undergoing orthopaedic surgery were randomly divided into the observation group and the control group with 290 cases in each,the observation group was treated with cefotiam by intravenous drip at 30-60 min before typeⅠ surgery,with a dose added for the patients with operation duration more than 3h;before type Ⅱ surgery,typeⅠ intraoperative surgery,intravenous drip of cefotiam was performed for 3 times with 8h once;the control group did not use antibiotics before or during the surgery,intravenous drip of cefotiam was performed after the surgery,with twice a day for 3-5d.RESULTS The postoperative morbidity of the observation group was 11.0%,antifebrile time(5.88±2.56)d,incision infections;as compared with the control group 12.1%,(5.65±2.67)d,and 3.5%,the differences were not statistically significant;the postoperative hospitalization duration of the observation group was(15.18±6.56)d,shorter than(19.89±7.13)d,the difference was statistically significant.CONCLUSION The application of single-agent before operation and the use of antibiotics later after the operation o Orthopaedic patients is an effective and feasible pattern for the prevention of infections,which is worthy of the clinical application.