The Levels of Serum Lipoprotein(a) and Fibronectin in Patients With Pregnancy-Induced Hypertension

Objective: Our aim was to investigate the changes of lipoprotein (a) and fibronectin (Fn) in the onset and development of pregnancy induced hypertension (PIH).Methods: The subjects were divided into PIH group (n=30, 16 moderate and 14 severe) and normal pregnancy group (n=20). The levels of Lp(a) and Fn in maternal and umbilical serum were detected by using immunoturbidimetry method.Results: (1)The levels of Lp(a) in maternal serum of patients with moderate PIH and severe PIH were significantly higher than that in the normalpregnancygroup (P0 01). (2) The level of Lp(a) in umbilical vein of patients with severe PIH was significantly higher than those of normal pregnancy group and patients with moderate PIH (P0 05).(3)The levels of Fn in maternal serum of patients with moderate PIH and severe PIH were significantly higher than that of normal pregnancy group (P0 05).(4)The level of Fn in umbilical vein of patients with moderate PIH was significantly higher than that of normal pregnancy group (P0 05).(5)The level of Fn in umbilical vein of patients with severe PIH was significantly higher than that of normal pregnancy group (P0 01).Conclusion: The increases of Lp(a) and Fn in serum inolves in the lesion of endothelium. The changes of their levels can help in the diagnosis and prognosis of PIH.