Propofol TCI and isoflurane anesthesia on the effects of rocuronium

Objective To investigate the neuromuscular effect of rocuronium under propofol target controlled infusion (TCI) anesthesia or isoflurane anesthesia. Methods Forty-eight ASA class Ⅰ or Ⅱ patients undergoing selective operations were randomly divided into propofol TCI group (group P, n=24) and isoflurane inhalation group (group I, n=24). All patients were induced with propofol TCI, fentanil and rocuronium 0.6 mg/kg. Patients in group P were maintained with propofol TCI and remifentanil, and those in group I with 1MAC isoflurane and remifentanil. The TOF mode of stimulation was used to monitor neuromuscular blocking variables of onset time, no-response time, the time to recovery of T1 to 25% of control, recovery index and the TOF ratio (TOFr) to 0.25.Results TOFr to 0.25 and recovery index were greater under isoflurane anesthesia than those under propofol-remifentanil anesthesia (P0.05). But there were no significant differences in the onset time, no-response time, and T1 25% recovery time between two groups. Conclusion Propofol TCI-remifentanil anesthesia has little effect on rocuronium but 1MAC isoflurane inhalation potentiates the neuromuscular effect of rocuronium.