Expression and Significance of p27 and cyclin E in Bladder Transitional Cell Carcinoma

Objective To investigate the significance of the protein expression of p27 and cyclin E in the progression and prognosis of bladder transitional cell carcinoma.Methods The pathological stage and histological grade were assessed in 121 patients with bladder transitional cell carcinoma.The expression of p27 and cyclin E was tested by immunohistochemical staining.Results The expression rate of p27 and cyclin E was 42.1% and 34.7%,respectively.Both p27 and cyclin E expression were related to histological grade of tumors but not to the pathological stage.A negative correlation was observed between p27 and cyclin E expression(P0.05).In patients with negative expression of p27,the five-year survival rate was lower in patients with positive expression of cyclin E than in those with negative expression of cyclin E(P0.05).Patients with positive expression of cyclin E and low expression of p27 had a poor prognosis.In patients with positive expression of p27,the expression of cyclin E had no relation with the 5-year survival rate.Conclusion p27 and cyclin E are important prognostic factors for patients with bladder transitional cell carcinoma.