Clinical significance of serum concentration of vascular endothelial growth factor in patients with gastric cancer

Objective:In this study,serum concentration of vascular endothelial growth factor(VEGF)was measured to detect its clinical significance in patients with gastric cancer,Methods;Enzyme linked immunosorbent assay(ELISA)were used to detect serum VEGF concentration in 51 cases of human gastric carcinoma,9 cases of chronic gastritis and 10 healthy controls.Results:Serum VEGF concentration was much higher(P0.05)in gastric cancer patients than that of chronic gastritis and healtby controls,But compared with healthy controls,serum VEGF concentration in chronic gastritis was not higher(P0.05).SerumVEGF concentration in gastric cancer patients were positively correlated with depth of invasion(P0.05),lymph node metastasis(P0.01),distant metastasis(P0.01),tumor stage(P0.05),histolohical type of tumor(P0.05)and growth style of tumor(P0.05),but no significant correletion with sex(P0.05).Conclusion:Serum VEGF concentration is closely correlated with invasion and metastasis in gastric carcinoma.