Investigation on the Dissolution Rate of Sanhuang Tablest in Vitro

Objective To investigate the dissolution velocity of Sanhuang Tablets in vitro from five factories.Methods 0.1 mol/L hydrochloric acid as dissolvent and rotating-basket method at 100 r/min, the cumulative dissolution percentage was determined by UV spectrophotometry.The dissolution parameters was obtained by Weibull distribution model and dealed with one-way ANOVA.Results The significant differences in dissolution parameters (T 50, T 90,m)(P0.01) of the five samples were discovered by statistical analysis.Conclusion It will be necessary to bring the dissolution determination method into the quality control standard for improving the quality and preparation technology of Sanhuang Tablets.