Effect of insulin interventional therapy on the prognosis of cerebral infarction with hyperglycemia

Objective To investigate the effect of insulin interventional therapy on the prognosis of cerebral infarction with hyperglycemia. Methods One hundred eighty-three cases were divided randomly into treatment group (93 cases) and control group (90 cases). Besides the routine medical therapy, treatment group was given dripping of soluble insulin. The dose of insulin was adjusted to maintain the blood sugar value on an empty stomach below 3.5～6.1 mmol/L. The total course of treatment was 14 days, average 20 u per day in the first week, 10～12 u per day in the second week. The score to the loss of nerve function was calculated separately at the 3rd, 7th and 21st day, to evaluate whether the treatment was effective.Results ① In the treatment group, the worsen rate on the 3rd was 9.68%, the effective rate on the 7th day was 16.67%, and on the 21st was 77.42%. The values in control group were 38.33%, 16.67% and 46.67%. There was significant difference between the two groups in each period. ② There were reductions of the insulin dose as the progress went by. Conclusion It is suggested that the insulin should have a positive effect on controlling the progress of cerebral infarction and improving the prognosis.