Clinical research on tiotropium bromide aerosol in treatment of COPD in stable with coronary heart disease in elderly patients

Objective To study the efficacy and safety of combined inhaled tiotropium bromide and seretide(50 μg/250 μg)in the treatment of chronic obstructive pulmonary disease(COPD) in stable with coronary heart disease(CHD).Method 65 patients of COPD in stable with coronary heart disease were divided into observation group(33 cases) and control group(32 cases).The control group was given seretide(50 μg/250 μg),observation group received the combination of tiotropium.Pulmonary function,dynamic electrocardiogram,liver and kideney function were made respectively before treatment,3 months and 6 months after treatment.Result After 6 months,the observation group were effective in ameliorate dyspnea,and the total effective rate in observation group(90.91%) was significantly higher than that in control group(71.88%) with significant difference(P0.05).After treatment,the pulmonary function in patients of both groups were obviously improved(P0.01),the improvement in observation group was more greater(P0.01).dDynamic electrocardiogram were no significant differences in all patients.Conclusion Salmeterol and fluticasone propionate combined tiotropium can significantly improve the clinical symptoms in patients of COPD in stable with coronary heart disease with safety.