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The Expression and Significance of P-glycoprotein and P53 Protein in Gastric Cancer

Xiaohua Zhang

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Abstract

Objective To study the expression of P-glycoprotein and P53 protein and ists relationship in gastric carcinoma. Method Thirty cases with gastric carinoma Were subjected to immunohistochemical to obseve the exptession of p-glycopretem and P53 protein and its relationship. Results the positive expression of p-glycoprotein was found in 60% and the positive expression of p53 protein was interrelated. Conclusions The result show that the p53 protein correlated with the multidrug resistance in gastric carcinoma.

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Objective To study the expression of P-glycoprotein and P53 protein and ists relationship in gastric carcinoma. Method Thirty cases with gastric carinoma Were subjected to immunohistochemical to obseve the exptession of p-glycopretem and P53 protein and its relationship. Results the positive expression of p-glycoprotein was found in 60% and the positive expression of p53 protein was interrelated. Conclusions The result show that the p53 protein correlated with the multidrug resistance in gastric carcinoma.

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Available abstract

Objective To study the expression of P-glycoprotein and P53 protein and ists relationship in gastric carcinoma. Method Thirty cases with gastric carinoma Were subjected to immunohistochemical to obseve the exptession of p-glycopretem and P53 protein and its relationship. Results the positive expression of p-glycoprotein was found in 60% and the positive expression of p53 protein was interrelated. Conclusions The result show that the p53 protein correlated with the multidrug resistance in gastric carcinoma.

Key concepts: P-glycoprotein, Immunohistochemistry, Gastric carcinoma, Glycoprotein, Multiple drug resistance, Protein expression, P53 protein, Cancer

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