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2011•Zhongguo laonianxue zazhiRequires access

Variation of the specific and non-specific immune function of mice with spleen deficiency and effect of Chinese medicine

Yong Duan

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Abstract

Objective To investigate the variation of the specific and non-specific immune function of mice with spleen deficiency and effect of Chinese medicine on them.Methods Mice were randomly divided into control,model,different dose of dunhuangdabao(DHDB) and positive control groups,8 mice in each group.Animal model of spleen deficiency was established.Effect of DHDB on the phagocytosis ratio of macrophage and phagocytosis index,T and B lymphocytes proliferation induced by ConA or LPS and NK cell activity were detected.Results The specific and non-specific immune function of mice with spleen deficiency was low.Compared with model group,DHDB could increase the phagocytosis ratio of macrophage and phagocytosis index,T and B lymphocytes proliferation and NK cell activity(P0.05) significantly.Conclusions DHDB can markedly improve part of the specific and non-specific immune in mice with spleen deficiency.

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What this paper is about

Objective To investigate the variation of the specific and non-specific immune function of mice with spleen deficiency and effect of Chinese medicine on them.Methods Mice were randomly divided into control,model,different dose of dunhuangdabao(DHDB) and positive control groups,8 mice in each group.Animal model of spleen deficiency was established.Effect of DHDB on the phagocytosis ratio of macrophage and phagocytosis index,T and B lymphocytes proliferation induced by ConA or LPS and NK cell activity were detected.Results The specific and non-specific immune function of mice with spleen deficiency was low.Compared with model group,DHDB could increase the phagocytosis ratio of macrophage and phagocytosis index,T and B lymphocytes proliferation and NK cell activity(P0.05) significantly.Conclusions DHDB can markedly improve part of the specific and non-specific immune in mice with spleen deficiency.

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Available abstract

Objective To investigate the variation of the specific and non-specific immune function of mice with spleen deficiency and effect of Chinese medicine on them.Methods Mice were randomly divided into control,model,different dose of dunhuangdabao(DHDB) and positive control groups,8 mice in each group.Animal model of spleen deficiency was established.Effect of DHDB on the phagocytosis ratio of macrophage and phagocytosis index,T and B lymphocytes proliferation induced by ConA or LPS and NK cell activity were detected.Results The specific and non-specific immune function of mice with spleen deficiency was low.Compared with model group,DHDB could increase the phagocytosis ratio of macrophage and phagocytosis index,T and B lymphocytes proliferation and NK cell activity(P0.05) significantly.Conclusions DHDB can markedly improve part of the specific and non-specific immune in mice with spleen deficiency.

Key concepts: Spleen, Phagocytosis, Immune system, Macrophage, Immunology, Biology, In vitro, Biochemistry

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