Effectiveness analysis on hydrochloride venlafaxine sustained-release tablets in treatment of depression

Objective:To explore the clinical efficacy and safety of hydrochloride venlafaxine sustained-release tablets on depression.Methods:60 patients with the depression diagnosed according to CCMD-3 were divided into hydrochloride venlafaxine sustained-release tablets(n=30) and amitriptyline(n=30) groups.The two groups were treated for 6 weeks.Clinical efficacies were assessed with the Hamiltion Depression Scale(HAMD) and Hamiltion Anxiety Scale(HAMA).The side effects were assessed by the Treatment Emergent Symptom Scale(TESS).Results: Effectual rate was higher in the research than in the control group(p0.05),and there was no significant difference in total effective rate between the 2 groups(p0.05).after treatment,scores of the HAMD and HAMA decreased more significantly in the research than in the control group,and differences were significant or the most significant(p0.05 or 0.01);side effects in the research group were milder and could remit voluntarily,while those in the control group were severe and should be treated by adjusting dosage or symptomatic treatment.Conclusions: Hydrochloride venlafaxine sustained-release tablets hasbetter efficacy,higher safety and well compliance in the treatment of Depression,but to hypertensive patients should be used carefully.