Clinical significance of coagulation function in acute progressive cerebral infarction

Objective To investigate the clinical significance of coagulation function in acute progressive cerebral infarction(APCI).Methods 78 patients with cerebral infarction who were admitted to our hospital within 48 hours after acute onset were divided into two groups,progressive group(n=22)and stable group(n=56).All the patients were matched with diagnosis by clinical standards referred to the fourth national cerebrovascular diseases meeting in 1995(SSS Scoring System)and were confirmed by computerized tomogramphy(CT).The patients'blood(2.7ml)was taken to examine the coagulation function.Results The mean fibrinogen(3.6± 0.6 g/L)in progressive group was significantly higher than that(2.5±0.6 g/L)in stable group(P0.05).There were no significance differences in prothrombin time(PT),prothrombin activity(PA),activated partial thromboplastin time(APTT)and thrombin time(TT)between the two groups.Conclusion The high levels of fibrinogen are one of the risk factors in acute progressive cerebral infarction.