Analysis on serum total bile acids and liver function levels and its clinical significance in patients with intrahepatic cholestasis of pregnancy

Objective To investigate the characteristics of the alteration of the serum total bile acids(TBA) and the liver function in patients with intrahepatic cholestasis of pregnancy (ICP) and to analyze its clinical significance. Methods The fasting serum TBA and the liver function (ALTAST、 GGT) levels were measured in 50 patients with ICP and 50 healthy women with pregnancy were collected and were measured in the same time as controls. The abnormal liver function and abnormal metabolism of TBA for ICP, the complications of mothers and fetus, and the pregnancy ending were observed and their relations were analyzed. Results The level of serum TBA in ICP group was(73.9±13.6) μmmol/L,which was higher than that(7.8±2.1) μmol/L in the control group(P0.01).The levels of serum ALT, AST and GGT in ICP group were(98.5±6.8)U/L,(84.2±5.6)U/L and(143.9±14.7)U/L respectively,which were obviously higher than those(32.5±5.1)U/L,(25.3±5.2)U/L and(35.1±4.5)U/L in the control group(P0.01).Conclusion For patients with ICP, serum TBA and liver function were sensitive index to reflect severe degree of the disease, and they possess important reference value in clinical diagnosis, verdict curative effect and clinical development of the diseases.