Pathogens isolated from blood culture specimens and their distribution and drug resistance.

OBJECTIVE To investigate the distribution and the drug resistance of pathogens in blood culture to conduct reasonable usage of antimicrobial agents in clinic.METHODS The blood samples were cultivated by using the Bactec 9120 system.Isolated colonies were identified and drug sensitivity was tested by MicroScan system.RESULTS A total of 452 strains of pathogenic bacteria were isolated from 3277 blood specimens,the positive rate was 13.8%.Gram-positive and Gram-negative bacilli bacteria accounted for 48.9% and 43.8%,respectively,and fungi for 7.3%.The most frequent pathogenic bacteria isolated were coagulase negative Staphylococcus,Escherichia coli and Staphylococcus aureus.No Gram-positive cocci strains were resistant to vancomycin.Gram-negative bacilli were highly susceptible to imipenem.CONCLUSIONS There are various pathogens identified from blood culture,and the drug resistance rate is high.The clinicians should monitor the changes in pathogens and trends of drug resistance in time,in order to give the patients correct antibiotic therapy and to control the cross-infection in hospital.